Your body contains an elaborate master communication system called the endocannabinoid System (ECS). Of all the systems regulated by the ECS, its role in regulating stress is one of the most important.
Endocannabinoid signaling is found throughout the key areas related to stress, in particular the Hypothalamic-Pituitary-Adrenal (HPA) Axis, which is responsible for controlling cortisol and other stress hormones.
Endocannabinoid receptors have also been discovered in the amygdala, part of the limbic system crucially involved in emotions and memory, in particular fear.
A functioning ECS in the HPA axis and amygdala allows the body to cope with high stress levels. When there is an endocannabinoid deficiency, there is an inability to adapt to chronic stress.
As a stress reducer, Hemp Extract works by reducing the body’s defensive responses to stressful events such as raised heart rate, blood pressure, and anxiety.
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[For more science-based evidence for the use of hemp extract read "Hemp Health Revolution: The A to Z Health Benefits of Hemp Extract"]
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Endogenous cannabinoid signaling is essential for stress adaptation.
*Neurosci Biobehav Rev. 2008 Aug;32(6):1152-60. doi: 10.1016/ j.neubiorev.2008.03.004. Epub 2008 Mar 18.
Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders.
*J Neurosci. 2010 Nov 10;30(45):14980-6. doi: 10.1523/JNEUROSCI. 4283-10.2010.Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output.
*J Exp Biol. 2014 Jan 1;217(Pt 1):102-8. doi: 10.1242/jeb.089730. Neuromodulators, stress and plasticity: a role for endocannabinoid signalling.
